Explain the functions of enzymes in DNA replication.

Explain the functions of enzymes in DNA replication. 1
Enzyme / ProteinSpecific Function
DNA pol IRemoves RNA primer and replaces it with newly synthesized DNA.
DNA pol IIIThe main enzyme adds nucleotides in the 5′-3′ direction.
HelicaseIt opens the DNA helix by breaking hydrogen bonds between the nitrogenous bases.
LigaseSeals the gaps between the Okazaki fragments to create one continuous DNA strand
PrimaseSynthesizes RNA primers needed to start replication
Sliding ClampHelps to hold the DNA polymerase in place when nucleotides are being added
TopoisomeraseHelps relieve the strain on DNA when unwinding by causing breaks, and then resealing the DNA

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